Metabolic Lean by Douglas Laboratories is a novel weight management formula that includes three branded and clinically studied ingredients-- Meratrim plant extract, Capsimax capsicum extract, and Zychrome chromium complex. This special combination of ingredients may improve lipolysis, thermogenic activity, and insulin function.† The ingredients in Metabolic Lean also help to increase adiponectin levels which facilitate proper fat metabolism and glucose regulation.†
FUNCTIONS Meratrim is a proprietary plant extract blend for weight management derived from two plants, Sphaeranthus indicus and Garcinia mangostana, traditionally used in Southeast Asian culture. Meratrim has been shown in two independent, randomized, double-blind, placebo-controlled clinical studies to significantly reduce body weight, BMI, and waist circumference within 8 weeks when used in combination with a diet and exercise plan.† Meratrim appears to achieve this by modulating the accumulation of fat while simultaneously increasing fat burning.† Toxicological studies on Meratrim have demonstrated a wide margin of safety. In vitro studies demonstrate that Meratrim modulates the expression of biomarkers that control adipogenesis and lipogenesis as follows:
• Reduces the expression of the peroxisome proliferator-activated receptor gamma (PPAR) hormone receptor. PPAR induces adipocyte-specific genes involved in the formation and growth of fat cells.†
• Reduces the expression of adipocyte differentiation related protein (ADRP). This is a signaling protein which facilitates the uptake of fatty acids to form lipid droplets and adipocyte differentiation.†
• Reduces the expression of cluster of differentiation 36 (CD36)—a trans-membrane receptor that facilitates fatty acid uptake by adipocytes.†
• Reduces perilipin expression.† Perilipins are adipocyte proteins that are localized at the surface of the lipid droplet and inhibit fat break down by restricting access of lipase to the lipid droplet.
Capsimax extract is a proprietary encapsulated form of premium, highly concentrated natural capsicum fruit extract manufactured from hot red peppers. Capsaicinoids are a group of compounds which cause the “heat” found in hot peppers. In fact, over the past 30 years, studies including animal and human subjects support the potential of red hot capsicum and capsaicinoids as a safe, effective ingredient to aid in weight management.† Benefits of capsicum and capsaicinoids in animal and human studies have shown that it helps manage appetite, supports healthy metabolism to burn calories, and helps induce thermogenesis.† Capsimax is a patent-pending encapsulated form of premium, highly concentrated natural capsicum extract. Using a proprietary matrix, Capsimax capsicum extract gives users the maximum effectiveness of capsaicinoids without any oral or gastric irritation, thus solving the problem of capsicum compliance.
Chromium Zychrome is a unique, patent-pending chromium complex consisting of chromium, niacin and L-cysteine (chromium dinicocysteinate). Seventeen chromium complexes were screened in preclinical studies in order to arrive at the complex found in Zychrome. In vitro and in vivo studies demonstrated that Zychrome is more efficacious than other forms of chromium in supporting healthy fasting glucose levels, glycated hemoglobin levels (HbA1c), insulin levels, CRP, MCP-1, ICAM-1 and oxidative stress levels.† These effects of Zychrome are mediated by the regulation of cell signal transduction pathways associated with insulin function, and glucose control.† A randomized, double-blind, placebo-controlled clinical study showed that Zychromesignificantly modulated the levels of insulin and insulin resistance as well as the cytokine TNF and protein carbonyl content, a marker of oxidative stress. Toxicological studies have demonstrated a wide margin of safety.
INDICATIONS Metabolic Lean is indicated as a dietary supplement for individuals desiring weight management support.